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It’s recommended that you take the allopurinol tablet once a day, ideally after eating breakfast.

Typically, allopurinol is prescribed alongside a fluid uptake, so try to drink two to three liters of fluids each day.

Allopurinol typically begins to lower uric acid levels within a few days to weeks of starting treatment. However, the full effect of allopurinol may take several weeks to months to be fully realized.

Regular monitoring of uric acid levels and symptoms is crucial during the initial phase of treatment with allopurinol. Healthcare providers may adjust the dosage as needed to achieve and maintain target uric acid levels and manage gout symptoms effectively.

There are several potential medication interactions when taking allopurinol. Certain blood pressure medications, penicillin antibiotics, anticoagulants, and diuretics can interact with allopurinol and/or lessen its effects.

Allopurinol remains in the body for three days after the last dose. With patients with impaired kidney function, this may be even longer. Salicylates (such as aspirin) can increase the rate at which the kidneys eliminate drugs, but should only be taken on the recommendation of your doctor.

The cost of allopurinol may vary depending on location or pharmacy, but typically a 20-tablet supply of 100 mg ranges from $10-$15.

There are certain foods and drinks to avoid while taking allopurinol to avoid interfering with the medication’s effectiveness and to limit gout flares.

• Avoid consuming alcohol – especially beer and spirits – as it can increase uric acid levels.
• Stay away from high-purine foods – including red meats, organ meats (kidney, liver), shellfish, anchovies and sardines – as foods rich in purine can avoid a rise in uric acid.
• NSAIDs – such as ibuprofen – may increase the risk of kidney problems.

It’s important to stay hydrated while using allopurinol to help flush out uric acid and prevent gout attacks. Do this especially in hot weather or during physical activity.

The most common side effects of allopurinol include:

• Skin rash
• Upset stomach
• Nausea or vomiting
• Diarrhea
• Headache
• Dizziness
• Changes in taste

Less commonly, allopurinol can cause more severe side effects, such as:

• Allergic reactions, including severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis
• Liver problems
• Blood disorders
• Kidney problems

If you experience any severe or persistent side effects while taking allopurinol, it's essential to contact your healthcare provider immediately. They can evaluate your symptoms and determine if any changes to your treatment plan are necessary.

LifeMD offers patients access to licensed healthcare providers who can offer guidance on healthcare concerns. Through our virtual platform, you can schedule same-day appointments and meet with a medical professional from the comfort of your home.

Your healthcare provider may prescribe you a medication if appropriate, and order it to your local pharmacy for your convenience. Skip the waiting room with LifeMD, make an appointment today to get started.