Get Prescription Lisinopril and Hydrochlorothiazide Online
- Diuretic and antihypertensive
- Treats high blood pressure
- Sold under brand names Prinizide, Zestoretic
Lisinopril and hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension).
- Lisinopril is an ACE inhibitor
- Hydrochlorothiazide is a diuretic (water pill)
This combination can also help reduce the risk of stroke, heart attack, and kidney problems in people with high blood pressure.
Lisinopril and hydrochlorothiazide is typically taken once a day, at the same time each day.
Lisinopril and hydrochlorothiazide work together to lower blood pressure through two different mechanisms.
Lisinopril helps relax blood vessels by clocking the enzyme that tightens them. This lowers resistance in the arteries and reduces the workload on your heart. Hydrochlorothiazide helps your body eliminate excess salt and water through urine, which reduces fluid volume in your bloodstream and lowers blood pressure.
You may qualify for lisinopril and hydrochlorothiazide if you’ve been diagnosed with high blood pressure and need more than one medication to get it under control.
Your healthcare provider will consider:
- Your blood pressure readings
- Any history of heart disease, stroke, or kidney problems
- How you’ve responded to other medications
- Your potassium levels and kidney function, since both drugs can affect these
It’s not usually the first treatment, but it may be prescribed if a single medication isn’t enough or if this combination fits your health needs.
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Dr. Banita Sehgal
Internal Medicine Physician
My approach to healthcare is rooted in building genuine partnerships with my patients.
Taking the time to understand their needs and goals helps us collaborate effectively and find the best path forward together. What I love most about my work is being someone they can count on — familiar, accessible, and focused on their well-being.
Frequently asked questions
Lisinopril and hydrochlorothiazide may be right for you if you have high blood pressure that isn’t well controlled with a single medication – or if your doctor thinks a combination approach will be more effective from the start.
Your provider will consider factors like:
- Your current blood pressure and overall heart risk
- Kidney function and electrolyte levels
- Whether you’ve had side effects from either medication in the past
- Other health conditions, like diabetes or heart failure
A simple blood test and blood pressure check can help determine if this combo is a safe and effective option for you.
The best time to take lisinopril and hydrochlorothiazide is usually in the morning, since the diuretic (hydrochlorothiazide) can make you urinate more often.
Taking it early in the day helps avoid nighttime trips to the bathroom. It’s also important to take it at the same time every day to keep your blood pressure stable. Be sure to always follow your healthcare provider’s instructions, as timing may vary based on your specific health needs.
It’s best to be cautious with alcohol while taking lisinopril and hydrochlorothiazide. Alcohol can lower your blood pressure even further, which may lead to dizziness, lightheadedness, or fainting – especially when standing up.
Lisinopril and hydrochlorothiazide typically do not cause weight gain. In fact, hydrochlorothiazide is a diuretic, so it may lead to temporary water weight loss when you first start taking it.
However, if you notice unexpected weight gain – especially if it’s rapid or comes with swelling in your legs, feet, or hands – it could be a sign of fluid retention or another issue and should be reported to your healthcare provider.
The most common side effects of lisinopril and hydrochlorothiazide include:
- Dizziness or lightheadedness, especially when standing up
- Dry cough (from lisinopril)
- Frequent urination (from hydrochlorothiazide)
- Headache
- Fatigue
- Low blood pressure
- Electrolyte imbalances (like low potassium or sodium)
Most side effects are mild, especially once your body adjusts. Still, if you notice symptoms like swelling, chest pain, or signs of an allergic reaction (such as facial swelling or difficulty breathing), contact your provider right away.
LifeMD offers patients access to licensed healthcare providers who can offer guidance on healthcare concerns. Through our virtual platform, you can schedule same-day appointments and meet with a medical professional from the comfort of your home.
Your healthcare provider may prescribe you a medication if appropriate, and order it to your local pharmacy for your convenience. Skip the waiting room with LifeMD, make an appointment today to get started.
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