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Lisinopril and hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension).
This combination can also help reduce the risk of stroke, heart attack, and kidney problems in people with high blood pressure.
Lisinopril and hydrochlorothiazide is typically taken once a day, at the same time each day.
Lisinopril and hydrochlorothiazide work together to lower blood pressure through two different mechanisms.
Lisinopril helps relax blood vessels by clocking the enzyme that tightens them. This lowers resistance in the arteries and reduces the workload on your heart. Hydrochlorothiazide helps your body eliminate excess salt and water through urine, which reduces fluid volume in your bloodstream and lowers blood pressure.
You may qualify for lisinopril and hydrochlorothiazide if you’ve been diagnosed with high blood pressure and need more than one medication to get it under control.
Your healthcare provider will consider:
It’s not usually the first treatment, but it may be prescribed if a single medication isn’t enough or if this combination fits your health needs.
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Lisinopril and hydrochlorothiazide may be right for you if you have high blood pressure that isn’t well controlled with a single medication – or if your doctor thinks a combination approach will be more effective from the start.
Your provider will consider factors like:
A simple blood test and blood pressure check can help determine if this combo is a safe and effective option for you.
The best time to take lisinopril and hydrochlorothiazide is usually in the morning, since the diuretic (hydrochlorothiazide) can make you urinate more often.
Taking it early in the day helps avoid nighttime trips to the bathroom. It’s also important to take it at the same time every day to keep your blood pressure stable. Be sure to always follow your healthcare provider’s instructions, as timing may vary based on your specific health needs.
It’s best to be cautious with alcohol while taking lisinopril and hydrochlorothiazide. Alcohol can lower your blood pressure even further, which may lead to dizziness, lightheadedness, or fainting – especially when standing up.
Lisinopril and hydrochlorothiazide typically do not cause weight gain. In fact, hydrochlorothiazide is a diuretic, so it may lead to temporary water weight loss when you first start taking it.
However, if you notice unexpected weight gain – especially if it’s rapid or comes with swelling in your legs, feet, or hands – it could be a sign of fluid retention or another issue and should be reported to your healthcare provider.
The most common side effects of lisinopril and hydrochlorothiazide include:
Most side effects are mild, especially once your body adjusts. Still, if you notice symptoms like swelling, chest pain, or signs of an allergic reaction (such as facial swelling or difficulty breathing), contact your provider right away.
Yes! With LifeMD, you can connect with a licensed healthcare provider from the comfort of your home within an hour. If appropriate, your provider may prescribe lisinopril and hydrochlorothiazide and send it directly to your local pharmacy.
For even more flexibility, a LifeMD+ membership gives you 24/7 access to care, same-day prescription refills, exclusive wellness perks, and easy access to lab testing — all designed to make managing your health simple and stress-free.
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