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Dr. Banita Sehgal
Internal Medicine Physician
My approach to healthcare is rooted in building genuine partnerships with my patients.
Taking the time to understand their needs and goals helps us collaborate effectively and find the best path forward together. What I love most about my work is being someone they can count on — familiar, accessible, and focused on their well-being.
Frequently asked questions
Methylprednisolone may be right for you if your symptoms are caused by significant inflammation – such as in asthma, arthritis, allergic reactions, or autoimmune disorders – and your provider believes a corticosteroid is necessary to control the flare or condition.
Your doctor will consider your diagnosis, overall health, other medications you’re taking, and how long you may need treatment before recommending it. Because corticosteroids can have side effects, they’re usually prescribed for the shortest duration and lowest effective dose needed to manage symptoms.
Methylprednisolone is not typically taken on an as-needed basis like a pain reliever. Instead, it's usually prescribed as a short-term course or part of a specific treatment plan with scheduled doses to manage inflammation or immune responses.
Taking it sporadically without medical guidance can increase the risk of side effects or interfere with your body’s natural hormone balance. Be sure to always follow your provider’s instructions and don’t start or stop methylprednisolone without checking in with them first.
Methylprednisolone and prednisolone are not exactly the same, but they’re closely related. Both are corticosteroids used to treat inflammation and immune-related conditions. However:
- Methylprednisolone is slightly more potent and has a longer duration of action than prednisolone.
- They may differ in how they’re absorbed and processed by the body.
- Doctors might choose one over the other based on the condition being treated, how it's administered (oral vs. injection), or your medical history.
Methylprednisolone typically stays in your system for about one to two days after your last dose, but its effects on the body can last longer. The drug’s half-life (how long it takes your body to eliminate half of the medication) is roughly 18 to 36 hours, depending on the dose and your metabolism.
However, even after it leaves your bloodstream, methylprednisolone can continue to affect your immune system and hormone balance for several days. If you've been on it for a longer period, your doctor may taper your dose gradually to help your body adjust.
No, methylprednisolone is not a controlled substance. It’s a prescription medication, but it’s not classified as having a risk for abuse or dependence like opioids or certain anxiety medications.
That being said, it does come with potential side effects – especially if taken at high doses or for long periods – so it should only be used under the guidance of a healthcare provider.
It’s best to limit or avoid alcohol while taking methylprednisolone. Both alcohol and corticosteroids like methylprednisolone can irritate the stomach lining, increasing the risk of ulcers, bleeding, or stomach upset. Drinking alcohol may also worsen side effects like mood changes, increased blood pressure, or weakened immune response.
The most common side effects of methylprednisolone include:
- Stomach upset (nausea, indigestion, or heartburn)
- Diarrhea or constipation
- Dizziness or headache
- Swelling (edema), especially in the hands, ankles, or feet
- Increased blood pressure
More serious but less common risks include stomach ulcers, kidney problems, and cardiovascular issues, especially with long-term use. Always take methylprednisolone exactly as prescribed and let your provider know if you experience any unusual or persistent symptoms.
LifeMD offers patients access to licensed healthcare providers who can offer guidance on healthcare concerns. Through our virtual platform, you can schedule same-day appointments and meet with a medical professional from the comfort of your home.
Your healthcare provider may prescribe you a medication if appropriate, and order it to your local pharmacy for your convenience. Skip the waiting room with LifeMD, make an appointment today to get started.