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- Treats post-menopausal symptoms
- Brand name prescription
- Estrogen medication
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What is Premarin?
Premarin is a prescription medication used to reduce symptoms of menopause. It has been used as part of treatment for hormone replacement therapy and for post-menopause. It can also help prevent osteoporosis after menopause.
The active ingredient Premarin is primarily made of three conjugated estrogens. It’s typically used to reduce hot flashes, night sweats, and vaginal dryness. Premarin is taken as conjugated estrogen tablets once daily with or without food or it can be used as a topical cream.
How does Premarin work?
Premarin works by restoring estrogen levels. After menopause, many women experience hot flashes and other symptoms because of a drop in estrogen levels.
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Meet our expert
My approach to healthcare is grounded in listening, education, and empowering patients to take an active role in their wellness.
I believe virtual care expands access and allows me to support patients with the same compassion and clinical excellence as an in-person visit. My goal is always to meet patients where they are and guide them toward safe, personalized, sustainable health outcomes.
Dina Whiteaker
APRN
Frequently
Asked
Questions
Who shouldn’t take Premarin?
Premarin is not recommended for people with a history of cancer, blood clots, liver disorders, or bleeding disorders. Be sure to let your healthcare provider know if you are experiencing irregular vaginal bleeding before taking Premarin.
Can you take Premarin while pregnant?
You should not take Premarin if you are pregnant or plan on becoming pregnant. Hormones from the medication can potentially pass into breast milk.
Has Premarin cream been discontinued?
Premarin cream has not been discontinued in the U.S., but it must be prescribed by a healthcare provider.
Does Premarin cause weight gain?
While weight gain is not a common symptom of Premarin, some people may see their weight fluctuate while taking the medication.
Can you drink while taking Premarin?
It’s not recommended to drink while taking Premarin. This may increase your risk of serious side effects.
What are the most common side effects of Premarin?
The most common side effects of Premarin include:
- Breast pain
- Irregular vaginal bleeding
- Abdominal pain
- Nausea
- Vomiting
- Yeast infections
- Fluid retention
It’s important to know that not everyone will experience the same side effects while taking Premarin. If you experience these or any additional symptoms, reach out to a healthcare provider.
What are the potential severe side effects of Premarin?
While they are rare, severe side effects from taking Premarin include:
- Ovarian cancer
- Hyperglycemia (high blood sugar)
- Blood clots
- Breast cancer
- Fibroids
- Heart attack
- Stroke
People over the age of 65 may have an increased risk of dementia. Be sure to speak with your healthcare provider immediately if you notice any serious side effects.
Does Premarin interact with any other medications?
Premarin may interact with progestins (synthetic progesterone). Using estrogens with progestins may increase your risk of heart attack, stroke, breast cancer, and blood clots. If you take thyroid medications, your healthcare provider may suggest adjusting your dosage while taking Premarin.
Be sure to let your healthcare provider know if you are taking other medications before starting Premarin.
Can LifeMD prescribe Premarin?
Yes! With LifeMD, you can connect with a licensed healthcare provider from the comfort of your home within an hour. If appropriate, your provider may prescribe Premarin and send it directly to your local pharmacy.
For even more flexibility, a LifeMD+ membership gives you 24/7 access to care, same-day prescription refills, exclusive wellness perks, and easy access to lab testing — all designed to make managing your health simple and stress-free.
Skip the waiting room. Join LifeMD and take control of your health today.
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