Get Prescription Trazodone HCI Online

  • Serotonin antagonist and reuptake inhibitor (SARI)
  • Treats depression
  • Sold under brand name Desyrel
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What is trazodone?

Trazodone is a prescription medication most commonly used to treat depression, but it’s also often prescribed off-label to help with sleep problems like insomnia. Trazodone belongs to a class of drugs called serotonin modulators, which help improve mood and promote relaxation. At lower doses, its sedating effects tend to be more noticeable – making it a popular option for people who have trouble falling or staying asleep.

How does trazodone work?

Trazodone works by affecting serotonin levels in the brain, a chemical that plays a key role in mood, sleep, and emotional balance. Specifically, it’s a serotonin antagonist and reuptake inhibitor (SARI). That means it:

  • Blocks the reuptake of serotonin, helping more of it stay active in the brain
  • Blocks certain serotonin receptors that can contribute to anxiety and wakefulness

At higher doses, this action helps treat depression by improving mood. At lower doses, the medication’s sedating effects tend to be stronger, which is why it's often prescribed off-label for insomnia.

How do I know if I qualify for trazodone?

You may qualify for trazodone if you’re experiencing symptoms of depression, anxiety, or insomnia, and other treatment options haven’t worked well for you or aren’t a good fit. It’s often considered when sleep problems are related to mood or stress. A healthcare provider will determine if trazodone is appropriate by considering:

  • Your current symptoms (like trouble sleeping or persistent low mood)
  • Any medications you're already taking
  • Your medical history, including heart rhythm issues or low blood pressure
  • How you’ve responded to other treatments in the past

Trazodone isn’t right for everyone, but if you're struggling with mood or sleep and looking for a non-habit-forming option, your provider may explore it as part of your treatment plan.

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