• Mental Health
• Depression
• Anxiety

LifeMD vs. Talkspace: How Do Their Mental Health Services Compare?

Published: September 15, 2025
Updated: September 15, 2025
4 mins

It’s not easy to reach out for help when you’re not feeling like yourself mentally. People often don’t want to place the burden of what they’re dealing with on their loved ones. Even those around you who may not outwardly look like they’re experiencing mental health challenges may need professional health services as well to navigate challenges.

Whether it’s coping with anxiety in front of a crowd or finding yourself constantly worried and distracted from daily tasks, there’s no shame in reaching out for assistance. Telehealth platforms like LifeMD and Talkspace connect users with licensed mental health professionals who can treat you virtually from the comfort of your home.

LifeMD vs. Talkspace

Telehealth allows those with mental health concerns to find quality treatment without sitting in waiting rooms for long hours or driving long distances.

LifeMD and Talkspace offer slightly different modes of treatment for mental health concerns. From medications to talk therapy, there are unique approaches in how each platform finds a treatment plan that supports your mental health needs.

LifeMD Mental Health Program Offerings

Before receiving mental health treatment with LifeMD, you start by answering a few questions about your symptoms, health history, and what you’re looking to get out of treatment. For anxiety and depression treatment, your plan also includes a video visit with a licensed healthcare provider. Once your review is completed, a LifeMD-affiliated healthcare provider can refer you to a therapist if needed and prescribe medication for those who qualify.

As of September 2025, LifeMD offers comprehensive mental health support for various mental health symptoms, like restlessness, extreme stress, fatigue, and more. More specifically, LifeMD primarily provides medications for the following mental health conditions:

• Social anxiety: Those with social anxiety may feel intense fear or stress of being judged by others in social settings.

• Performance anxiety: Performance anxiety is a type of social anxiety disorder. For those with performance anxiety, getting up in front of others in public speaking environments is challenging.

• Generalized anxiety disorder (GAD): The main symptoms of generalized anxiety disorder are feelings of intense worry and anxiety. 

• Depression: Also referred to as major depressive disorder, depression is a mental health condition causing intense mood swings and persistent emotions of sadness. Depression can affect how well you sleep, eat, and the social interactions you have with others.

• Insomnia: Those with insomnia have trouble falling asleep, staying asleep, or consistently getting quality sleep. Insomnia may occur due to stress, trauma, and major life changes.

• Post-traumatic stress disorder (PTSD): PTSD is triggered by traumatic experiences in a person’s life. Those with PTSD may experience intense distress from certain triggers that remind them of a specific event in the past.

You can use LifeMD on an as-needed basis that works with your financial situation for social and performance anxiety. With the LifeMD app, you can conveniently keep track of medication refills, referrals, and other aspects of your treatment.

Through secure messaging, you can regularly communicate with your provider about your mental healthcare for any of the conditions listed, even when you’re not receiving a prescription refill.

LifeMD Mental Health Program Costs

As of September 2025, the cost of receiving prescription medication and psychiatric care services from LifeMD starts at $49. The cost of the program covers consultations and secure messaging between you and your provider. 

Prices may vary depending on the medication prescribed to you and your insurance coverage. If a LifeMD-affiliated provider refers you to a specialized doctor, prices may vary for services outside of LifeMD.

Talkspace Mental Health Program Offerings

As of September 2025, Talkspace offers services for talk therapy and mental health medication tailored to your personalized experience. The first step is to answer a short questionnaire online before scheduling a video appointment with a licensed mental health provider. 

A healthcare provider will assess your needs and prescribe medication if you qualify. Talkspace also works with most major insurers to provide talk therapy services without a referral.

Talkspace focuses on treatment for the following mental health conditions:

• OCD (obsessive compulsive disorder): OCD is a mental health condition that can lead to repetitive thoughts and behaviors outside of your control.

• ADHD (attention deficit/hyperactivity disorder): Children are typically diagnosed with ADHD when they show signs of inattention, restlessness, and impulsivity. However, you can still be diagnosed with ADHD later in life.

Other mental health conditions Talkspace treats include the following:

• Social anxiety

• Anxiety

• Depression

• PTSD

In addition to traditional talk therapy, Talkspace offers the following therapy approaches:

• Dialectical behavior therapy (DBT): In dialectical behavior therapy, a therapist helps you to think differently about your approach to negative thoughts and emotional processes.

• Mentalization therapy: This form of therapy focuses on reframing your thinking to help with regulating your emotions. Mentalization therapy is ideal for those with borderline personality disorder (BPD).

• Emotion-focused therapy (EFT): You can participate in EFT alone or with loved ones. A licensed therapist helps you work on communication skills and conflict resolution with others.

• Exposure therapy: Exposure therapy is most commonly recommended to those with anxiety disorders or phobias. It involves working with a therapist to find the best method for confronting a phobia or source of anxiety.

• Somatic therapy

• Grief counseling: If you’ve experienced any loss or gone through a traumatic event in your life, Talkspace can connect you with a licensed healthcare provider to help you navigate grief.

• Humanistic therapy: If you don’t have a specific mental health concern, humanistic therapists can help you develop preventative techniques for when mental health challenges arise.

• Cognitive behavioral therapy (CBT): The CBT approach helps a person focus more on present issues than dwelling on the past.

Talkspace Mental Health Program Costs

Talkspace treatment options may vary depending on your insurance coverage, the therapy option you choose, and which subscription plan you’re under. As of September 2025, prices for a subscription with a therapist start at $69. This plan includes secure messaging with your therapist and the ability to schedule extra sessions for an additional cost.

If you also need medication as part of your treatment, only psychiatrists with Talkspace can prescribe medications for mental health treatment. Talkspace offers single-session costs at $22 a session and discounted bundled pricing starting at $435 for an initial evaluation and one follow-up session.

Mental Health Medications: LifeMD vs. Talkspace

LifeMD medications

Every LifeMD treatment is tailored to your personalized needs. Through LifeMD, you can receive a prescription for the following mental health medications:

• Wellbutrin SR® (bupropion SR): Wellbutrin is an antidepressant used to treat depression and tobacco withdrawal primarily.

• Prozac® (fluoxetine): Fluoxetine works by increasing serotonin levels in the brain. It’s prescribed to treat various mental health conditions like depression and anxiety disorders. Depending on your diagnosis, a healthcare provider may adjust your fluoxetine dosage over time.

• Buspar® (buspirone HCI): An FDA-approved medication for treating anxiety disorders by activating certain neurotransmitters in the brain and increasing serotonin levels.

• Cymbalta® (duloxetine): Duloxetine helps to increase serotonin and norepinephrine in the brain to regulate your mood and improve other common depressive symptoms.

• Zoloft® (sertraline): Sertraline helps to improve anxiety and depressive symptoms by activating mood-regulating neurotransmitters in the brain. Serotonin blocks the reabsorption of serotonin into neurons in the brain.

• Lexapro® (escitalopram): Escitalopram is an SSRI (selective serotonin reuptake inhibitor) that works by increasing serotonin levels in the brain. It’s prescribed to treat symptoms of depression and anxiety.

• Inderal® (propranolol): Propranolol is used to treat anxiety, some heart conditions, and migraines. 

• Celexa® (citalopram): Citalopram treats depression by increasing serotonin in the brain. It’s classified as an SSRI.

• Effexor (venlafaxine): Venlafaxine is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). It treats major depressive disorder and anxiety disorders by increasing serotonin and norepinephrine in the brain.

• Paxil® (paroxetine): Paroxetine can treat depression, social anxiety disorder, and other mental health conditions. It works by increasing serotonin levels in the brain.

Talkspace medications

Through Talkspace, you can connect with a licensed psychiatrist who may prescribe one of the following medications:

• Remeron (mirtazapine): Mirtazapine treats major depressive disorder, anxiety, OCD, and other mental health conditions. It works by enhancing the levels of noradrenaline and serotonin in the brain.

• Abilify® (aripiprazole): Aripiprazole is prescribed to treat depression, bipolar disorder, and schizophrenia. It works by balancing dopamine and serotonin levels in the brain.

• Lamictal (lamotrigine): A mood stabilizer and antiepileptic medication prescribed to treat bipolar disorder. Lamotrigine works by altering chemicals in the brain to manage extreme mood swings and depressive episodes.

• Desyrel® (trazodone): A healthcare provider may prescribe trazodone to help those with depression sleep. Trazodone works by increasing serotonin levels in the brain.

• Lithium: Lithium is a mood stabilizer helping to manage symptoms of depression, bipolar disorder, and schizophrenia.

• Seroquel (quetiapine): Quetiapine may help improve mood and behavior patterns in those with schizophrenia, bipolar depression, or depression.

• Hemangeol® (propranolol): Hemangeol is a beta-blocker that helps to treat heart issues, high blood pressure, and anxiety symptoms.

• Silenor® (doxepin): Doxepin helps those with insomnia at lower doses and anxiety and depression at higher doses.

• Trintellix (vortioxetine): An antidepressant that treats major depressive disorder by increasing serotonin levels. Vortioxetine may also improve overall cognitive function.

Other medications a Talkspace-affiliated provider may prescribe if you qualify:

• Zoloft (sertraline)

• Celexa (citalopram)

• Prozac (fluoxetine)

• Paxil (paroxetine)

• Lexapro (escitalopram)

• Buspar (buspirone)

• Cymbalta (duloxetine)

Where Can I Learn More About Mental Health Support?

With LifeMD, you can meet with a licensed mental healthcare provider to figure out where to start with taking better care of your mental health. The LifeMD Mental Health Program offers flexible, virtual treatment tailored to your individual mental health needs.

Whether you’re navigating anxious feelings in your work environment or depressive symptoms in your everyday life, LifeMD is here to help.

Complete a brief intake form to start feeling like your best self today.