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Get Amitriptyline Online

  • FDA-approved to treat depression in adults
  • Generic Elavil
  • Known as a tricyclic antidepressant
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745,000+ Patients Served
What is amitriptyline?

Amitriptyline is a daily prescription medication that was originally developed to treat depression in adults. It may also be prescribed off-label to treat chronic pain syndrome, anxiety, and insomnia.

How does amitriptyline work?

Amitriptyline is a tricyclic antidepressant (TCA) medication primarily used to treat depression.

Amitriptyline increases the levels of neurotransmitters – specifically serotonin and norepinephrine – by blocking their reuptake by nerve cells. This leads to an increase in the overall amount of serotonin and norepinephrine available in the brain, which can help improve mood and reduce feelings of pain.

Additionally, amitriptyline has sedative effects, which can be beneficial for treating insomnia and other sleep disturbances. It also has anticholinergic properties, which can help alleviate certain symptoms like bladder problems, gastrointestinal issues, and dry mouth.

It's important to note that amitriptyline should only be taken under the supervision of a healthcare provider, as it can have significant side effects and may interact with other medications.

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Meet our expert


My approach to healthcare is grounded in listening, education, and empowering patients to take an active role in their wellness.

I believe virtual care expands access and allows me to support patients with the same compassion and clinical excellence as an in-person visit. My goal is always to meet patients where they are and guide them toward safe, personalized, sustainable health outcomes.

Dina Whiteaker

APRN

Frequently
Asked
Questions

When is the best time to take amitriptyline?

Generally, amitriptyline is taken at bedtime due to its sedative effect, which can help improve sleep quality.

However, some people may prefer to take it earlier in the evening to minimize daytime drowsiness or before engaging in activities that require alertness, such as driving or operating machinery.

How long does it take amitriptyline to work?

Amitriptyline can begin to take effect after one to two weeks, but its full effects may not be noticeable for up to six weeks.

Does amitriptyline cause weight gain?

Yes, weight gain is a common side effect reported by some people taking amitriptyline. One study found that people taking amitriptyline gained between 1 lb and 16 lbs.

Health experts are still not sure what the exact cause of this is, but some speculate that appetite improves once depression symptoms lessen.

Is amitriptyline a controlled substance?

Amitriptyline is not classified as a controlled substance in the United States, but it does require a prescription.

However, even though it is not a controlled substance, amitriptyline should be used with caution and only under the supervision of a healthcare provider due to its potential for side effects and interactions with other medications.

Is it safe to take other medications while on amitriptyline?

Amitriptyline can interact with various medications, affecting its effectiveness or increasing the risk of side effects.

Some medications that may interact with amitriptyline include:

  • Other antidepressants, such as SSRIs, SNRIs, MAOIs, or other TCAs
  • Anticholinergic medications, including some antihistamines, antispasmodics, and medications for overactive bladder
  • Certain antihypertensive drugs
  • Drugs that affect liver enzymes, such as certain antifungal medications, antibiotics, or antivirals
  • Central nervous system depressants, such as alcohol, sedatives, or opioids

Additionally, combining amitriptyline with certain medications may increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by high levels of serotonin in the brain.

Symptoms of serotonin syndrome may include agitation, hallucinations, rapid heartbeat, fever, excessive sweating, shivering, tremors, muscle twitching, and gastrointestinal issues.

What are the most common side effects of amitriptyline?

The most common side effects of amitriptyline include:

  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Weight gain
  • Increased heart rate
  • Tremors
  • Sweating

Less common but more serious side effects may include:

  • Confusion or hallucinations
  • Irregular heartbeat
  • Difficulty urinating
  • Seizures
  • Allergic reactions (rash, itching, swelling)

If you experience any severe or persistent side effects while taking amitriptyline, it's essential to contact your healthcare provider immediately. They can evaluate your symptoms and determine if any changes to your treatment plan are necessary.

Additionally, abrupt discontinuation of amitriptyline should be avoided, as it may lead to withdrawal symptoms. Always consult with your healthcare provider before making any changes to your medication regimen.

Can LifeMD prescribe amitriptyline?

Yes! With LifeMD, you can connect with a licensed healthcare provider from the comfort of your home within an hour. If appropriate, your provider may prescribe amitriptyline and send it directly to your local pharmacy.

For even more flexibility, a LifeMD+ membership gives you 24/7 access to care, same-day prescription refills, exclusive wellness perks, and easy access to lab testing — all designed to make managing your health simple and stress-free.

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